Vitamin B12 deficiency can also cause symptoms of mania and psychosis, fatigue, memory impairment, irritability, depression and personality changes. | At the same time the patient was referred for treatment of Helicobacter pylori and was prescribed clarithromycin 1000 mg/day, lansoprazole 60 mg/day and amoxicillin 2000 mg/day. weeks compared to changes in psychometric tests. Here we report a case of vitamin B 12 deficiency in a 16-year old, male adolescent who presented with mixed mood disorder symptoms with psychotic features. Yet it is well-established in the scientific literature that people with B12 … Dogan M, Ozdemir O, Sal EA, Dogan SZ, Ozdemir P, Cesur Y, Caksen H: Psychotic disorder and extrapyramidal symptoms associated with vitamin B12 and folate deficiency. By using this website, you agree to our Another interesting feature of both our patient and that reported by Dogan and colleagues seem to be the prominence of extra-pyramidal symptoms in presentation [8]. Turkish. People with this vitamin deficiency have manic mood swings, where they are depressed or overconfident. Turkish, Kostakoglu Anıl E, Batur S, Tiryaki A, Gögüs A: The reliability and validity of the Turkish version of the Positive and Negative Syndrome Scale (PANSS). Despite the general misconception that B12 deficiency only affects women over 60, this condition does not discriminate. 2004, 11: 109-116. Follow-up endoscopy and biopsy at the first month demonstrated eradication of H. pylori. Vitamin B12 deficiency can also cause symptoms of mania and psychosis.” Schizophr Res. Psychiatric manifestations can occur in the presence of low serum B12 levels but in the absence of the other well recognized neurological and haematological abnormalities of pernicious anemia. My hypothesis is that since B12 is depleted by illness and by stress, the 6 year period of anxiety/stress/depression in my teens may have depleted my B12. It doesn’t work alone; however. Inadequate dietary intake can be an issue, as can inadequate absorption of what you eat. To illustrate this illness we reviewed the literature regarding psychopathology associated with B12 deficiency. Google Scholar. The patient was not vegetarian. Prevalence of Vitamin B12 Deficiency and its Associated Factors among Patients with Type 2 Diabetes Mellitus on Metformin from a District in Malaysia. knocking and ringing), olfactory (i.e. The time course of changes in BDI, BAI, PANSS and its subscales, YMRS and ESRS according to Vitamin B12 levels is illustrated in Figure 1. The patient was not vegetarian. 2015 Dec;41(6):550-5. doi: 10.1016/j.encep.2015.07.004. 2003, 29: 560-565. An iron deficiency was associated (serum iron=7 micromol/l; serum ferritin concentration=24 mg/l; serum transferrin concentration=3,16 g/l). 1988, 12: 163-172. A mild deficiency may not cause any discernible symptoms, but as the deficiency becomes more significant, symptoms of anemia may result, such as weakness, fatigue, light-headedness, rapid … Vanderzeypen F, Bier JC, Genevrois C, Mendlewicz J, Lotstra F. Debien C, De Chouly De Lenclave MB, Foutrein P, Bailly D. Bopp-Kistler I, Rüegger-Frey B, Grob D, Six P. Praxis (Bern 1994). The usual dose range of risperidone for acute psychosis and mood disorder is reported to be 2–8 mg/day while we have started risperidon at 0.5 mg/day to help stabilize the patient while the medical work-up and treatments were being completed [18]. 10.1016/1054-139X(95)00108-5. [Frontal dementia or dementia praecox? Vitamin B12 plays a vital role in producing brain chemicals that affect mood and other brain functions. Vitamin B12 is one of the essential vitamins affecting various systems of the body. Among the most common are: Dementia Memory loss; Cognitive decline Cognitive disorders; Severe poor concentration; Depression; Schizophrenia; Mania; Katatonia; Paranoia; Psychosis; Delusions; Delirium; Sometimes these symptoms can be fully or partially treated with vitamin B12 (1). Although concurrent administration of risperidone in our patient may be considered as a limitation in light of reports of improvement in psychotic symptoms as early as the first week, the fact that the administered dose of 0.5 mg/day was lower than doses recommended for controlling acute psychosis and mood disorders may support the beneficial effect of treatment with Vitamin B12 [18]. Google Scholar. She had history of diabetes, hypertension and femoral prosthesis. A thyroid hormones replacement was started and she continued to receive Monthly B12 replacement. Endoscopy and biopsy revealed atrophy of the gastric mucosa with Helicobacter Pylori colonization. The good news is this can work for some people with the mthfr gene mutation but should never be the first thing you do to treat the condition, the bad news is that often it is not the best place to start and in many cases can cause symptoms of methylfolate side effects. This case was presented as a poster at the 14th Adolescence Days (10th – 12th December 2009, Ankara, TURKEY). No stressors were present. PubMed Google Scholar. The symptoms may include agitation, irritability, negativism, confusion, disorientation, amnesia, impaired concentration and attention and insomnia; while psychiatric disorders that may be diagnosed in patients having vitamin B12 deficiency include depression, bipolar disorder, panic disorder, psychosis, phobias and dementia [1–6]. Fundic biopsy, realized by fibroscopy, revealed fundic atrophia and intestinal metaplasia compatible with Biermers' disease. Vitamins are a vital part of our life, they ensure the proper working of our internal organs and our body in general, a deficiency in either one can alter the processes of the body. AET and RB diagnosed the patient, provided treatment and follow-up, GU helped write and prepare manuscript and AE supervised manuscript preparation and evaluated final draft, providing suggestions for discussion. The pathophysiology of extrapyramidal symptoms in patients with Vitamin B12 deficiency is far from clear, although some indirect evidence exists. There was no previous history of compulsive shopping or buying sprees. Conclusion - We recommend consideration of B12 deficiency and serum B12 determinations in all the patients with organic mental disorders, atypical psychiatric symptoms and fluctuation of symptomatology. Speech was hypo-phonic, thought process was sluggish. Eur J Pediatr. B12 deficiency was depression, mania, psychotic symptoms, cognitive impairment, dementia, delirium, acute confusional states and obsessive compulsive disorder. 2001, 13: 107-114. th Durand C: Psychiatric manifestions of vitamin B 12 defiency: A case report. 1976, 114: 113. He refused to go to school and when sent became truant frequently. An evaluation with BDI and BAI revealed scores of 9 and 15, respectively while Evaluation with ESRS and YMRS yielded a score of 3 for both. Her neurologic examination, cerebral scanner and EEG were postponed because of uncooperation. She had a Capgras' syndrome and delusion of persecution. Mme V. appeared euphoric, her speech was very rapid with play on words and overactivity. J Food Sci Technol. 1997, 56: 925-930. that he had sinned and would be punished) arose and the patient reported that his thoughts were broadcast so that others can read and understand his thoughts. Turkish: Journal of Psychology, 3-13. Vitamin B12 deficiency can also cause symptoms of mania and psychosis.” A visit on the second week revealed no psychotic features. A follow-up endoscopy and biopsy at the first month revealed that H. pylori were eradicated from the gastric mucosa. 1999 Nov 4;88(45):1867-75. Serious side effects can occur when taking vitamin B12, including chest pain, shortness of breath, swelling, unusual warmth, and redness or pain in an arm or leg. This site needs JavaScript to work properly. Below are the links to the authors’ original submitted files for images. Google Scholar, Sharrief AZ, Raffel J, Zee DS: Vitamin B12 deficiency with bilateral globus pallidus abnormalities. His teachers also reported fidgetiness and impulsivity which was especially prominent in mathematics lessons. A vitamin B12 deficiency can cause dementia and psychosis, as explained by Dr. Simon. 1989, Volume 7. Similarly, when high doses of vitamin B2, usually referred to as riboflavin is taken, it can cause hypotension or low blood pressure. Ammouri W, Tazi ZM, Harmouche H, Maamar M, Adnaoui M. J Med Case Rep. 2017 Sep 2;11(1):250. doi: 10.1186/s13256-017-1415-z. Hisli N: The reliability and validity of Beck Depression Inventory for university students. Reynolds E: Vitamin B 12, folic acid, and the nervous system. A neurologic examination was possible because of cooperation. Psychiatric manifestations are frequently associated with pernicious anemia including depression, mania, psychosis, dementia. For a full list of symptoms please click here. Correspondence to 2009, 55: 205-207. Phenytoin Toxicity Manifesting as Acute Psychosis: An Uncommon Side Effect of a Common Drug. “Vitamin B12 deficiency can potentially cause severe and irreversible damage, especially to the brain and nervous system […] especially in elderly people (over age 60) who produce less stomach acid as they age, thereby increasing their probability of B12 deficiencies. Google Scholar. 10.1016/j.schres.2005.02.013. The cerebral scan and EEG were normal. People with B12 deficiency have an increased risk of developing psychosis, mania and dementia. Written informed consent was obtained from the patient for publication of this Case Report and any accompanying images. Although the lack of evaluation of volumes of basal ganglia in our patient may also be a limitation of our study, it may be said that future studies evaluating volumes of basal ganglia in patients with Vitamin B12 deficiency are needed. CAS This study reports a case of vitamin B12 deficiency in an adolescent who presented with mixed mood disorder symptoms with psychotic features as well as extra-pyramidal symptoms and its response to Vitamin B12 treatment. Romberg’s sign was negative and cerebellar tests were normal. Google Scholar. Laboratory evaluations were normal. It may cause more of a dermatitis that may resemble mild non-pustular acne. Child and Adolescent Psychiatry and Mental Health, http://creativecommons.org/licenses/by/2.0. All the tendon reflexes of inferior members were absent. 3. It is also unclear why Vitamin B12 deficiency leads to prominent neuro-psychological symptoms in some patients and not others. Venous thromboembolism and hyperhomocysteinemia as first manifestation of pernicious anemia: a case series. The lack of evaluation of volumes of specific brain structures, concurrent administration of an atypical antipsychotic along with vitamin B12, further evaluation of small intestine flora to determine the causes of bacterial over growth other than H. pylori, evaluation of RBC folate levels along with levels in serum of patient, evaluation of Homocysteine levels and testing for mutations in MTHFR and methyl-malonyl coA mutase, celiac antibodies and anti-parietal cell titres may be counted among the limitations of the case presentation. Yes, it can. HIV (ELISA) was negative. Her mental state improved dramatically within a few days. Chief complaints were “irritability, regressive behavior, apathy, crying and truancy” which lasted for a year. Department of Child and Adolescent Psychiatry, Assistant Professor, Abant Izzet Baysal University Medical Faculty, Baysal, Turkey, Psychiatrist, Elazig Hospital for Mental Disorders, Elazig, Turkey, Child and Adolescent Psychiatrist, Private Practice, Ankara, Turkey, Associate Professor, Department of Child and Adolescent Psychiatry, Bakirkoy Prof. Dr. Mazhar Osman Hospital for Mental Health and Nervous Disorders, Osman, Turkey, Abant Izzet Baysal Universitesi, Tip Fakültesi, Cocuk ve Ergen Psikiyatri Anabilim Dali, 14280, Golkoy, Bolu, Turkey, You can also search for this author in Here are some of the red-light signs of a deficit of this particular vitamin. Evaluation with The Extrapyramidal Symptom Rating Scale (ESRS) yielded a score of 19, with items of bradykinesia and parkinsonism being positive [10]. Neurons lack this pathway and are dependent on glia for production, thereby rendering them more susceptible to oxidative damage [1]. Psychotic symptoms were evaluated with Positive and Negative Syndrome Scale and the patient scored 20, 23 and 56 for the Positive, Negative and General Psychopathology subscales (Total 99) [15]. Serious Side Effects. Many medications can decrease absorption, as can some foods. The course of improvement in psychometric measures with changes in Vitamin B12 levels may also support this hypothesis (Figure 1). When the amount of vitamin B1, also known as thiamine exceeds the normal levels in the body, it can cause hypertension or high blood pressure. This can cause tingling and numbness in your hands and feet, muscle weakness, and loss of reflexes. volume 6, Article number: 25 (2012) Evaluation of Vitamin B12 and folate levels may be prudent in children and adolescents with affective complaints of abrupt onset and with accompanying psychotic/motor features. A Schilling test was administered to determine the etiology of Vitamin B12 deficiency and it was observed that radiolabeled Vitamin B12 levels were low both for Stage I and II of the test which was thought to reflect malabsorbtion [11]. But a study in JAMA Network Open suggests that very high blood levels of vitamin B12 may be life-threatening. Vitamin B12 deficiency may lead to nerve damage. Also, we could neither explain the reduction in Hb in absence of bone marrow RBC precursor megaloblastosis nor the rarity of this presentation in face of prevelance of mutations in MTHFR/borderline low Hb and Vitamin B12 levels or the presence of Romberg Sign along with extrapyramidal symptoms and therefore the observed presentation may be deemed spurious. th 2012, In: Harper’s Illustrated Biochemistry. Psychometric testing with the Beck Depression (BDI) and Anxiety Inventories (BAI) revealed scores of 35 (Cut-off score = 17, Severe Depressive Symptoms) and 36 (Without a clinically defined cut-off score albeit denoting severe anxiety), respectively [12, 13]. What Causes Low Ferritin and B12? Methyl-folate is pretty busy. Thought content was found to be impoverished and dominated by somatic complaints, delusions of reference, guilt and thought broadcasting. PANSS scores for positive, negative and general psychopathology subscales were 13, 15 and 36 respectively (Total 64). Terms and Conditions, Dopamine also stimulates methylation of phospholipids in the neuronal membrane and this reaction depends on single carbon folate pathway, thereby underlining the importance of the relationship between dopaminergic neurotransmission and single carbon metabolism [23]. Up to now, reports of psychiatric disorders due to vitamin B12 deficiency mostly focused on middle aged and elderly patients and pediatric cases are reported to be rare [7–9]. Middleman AB, Emans SJ, Cox J: Nutritional vitamin B12 deficiency and folate deficiency in an adolescent patient presenting with anemia, weight loss, and poor school performance. Chouinard G, Margolese HC: Manual for The Extrapyramidal Symptom Rating Scale (ESRS). The patient had started to display anxiety during separation from his mother, wept frequently and complained of vague pains, lethargy, forgetfulness and reduced concentration alternating with racing thoughts, irritability, anhedonia, distractibility, reduced sleep and appetite. Extrapyramidal symptoms were reduced. Mental or psychological changes may precede haematological signs by Months or Years. Vitamin B12 – an Essential Vitamin for the Nerves. Chen Z, Karaplis AC, Ackerman SL, Pogribny IP, Melnyk S, Lussier-Cacan S, Chen MF, Pai A, John SW, Smith RS, Bottiglieri T, Bagley P, Selhub J, Rudnicki MA, James SJ, Rozen R: Mice deficient in methlyene-tetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathy and aortic lipid deposition. B12 levels should be evaluated with treatment resistant depressive disorders, dementia, psychosis or risk factors for malnutrition such as alcoholism or advancing age associated with neurological symptoms, anemia, malabsorption, gastrointestinal surgery, parasite infestation or strict vegetarian diet. Romberg’s sign was present. A peripheral blood smear with Wright’s stain was found to be normal. Cookies policy. 2020 Feb;57(2):745-753. doi: 10.1007/s13197-019-04107-8. Psychomotor activity and appetite were reduced. The patient was followed for another 6 months at monthly intervals and the psychiatric symptoms did not recur at the time of last evaluation. 2019 Apr-Jun;14(2):532-534. doi: 10.4103/ajns.AJNS_86_18. Neurological examination revealed glossitis, ataxia, rigidity in both shoulders, cog-wheel rigidity in the left elbow, bilateral problems of coordination in cerebellar examination, reduced swinging of the arms and masked face. PubMed Google Scholar. Vitamin B12 deficiency can also cause symptoms of mania and psychosis.” 1984, 25 (9): 1032-1039. They can be the initial symptoms or the only ones. Past medical history and family history was normal. Physical and neurological examination revealed glossitis, ataxia, rigidity in both shoulders, cog-wheel rigidity in the left elbow, bilateral problems of coordination in cerebellar examination, reduced swinging of the arms and masked face. Vitamin B12 is one of the essential vitamins affecting various systems of the body. After one week of treatment the only remaining symptoms were lability of mood, delusion of persecution, Capgras' syndrome but disappeared totally 9 days after the beginning of the treatment. Six Months after her hospitalisation, she presented an hypothyroidism (TSH=3,780; T3=1,35; T4=1,08). CAS | Please enable it to take advantage of the complete set of features! Kumar S: Vitamin B12 deficiency presenting with an acute reversible extrapyramidaly syndrome. Risperidone was stopped and parenteral Vitamin B12 treatment was continued with monthly injections for 3 months. Davoren JB, Davoren JB, Blood Disorders: In Pathophysiology of Disease,. She had no history of psychiatric problems. Both the patient and his mother reported that apathy, crying, regressive behavior and truancy were reduced. NIH Regardless of its limitations, our case may underline the observation that mood disorders with psychotic features especially with accompanying extrapyramidal symptoms lacking a clear etiology may be rare manifestation of vitamin B12 and/or folate deficiency in children and adolescents and be potentially amenable to treatment. working at the Biochemistry Laboratory of the Elazig Hospital for Mental Disorders for her help biochemical analysis and suggestions. It may also be posited that patients with less severe mutations of methyl-malonyl coA mutase may be asymptomatic initially and reduced activity of the enzyme, perhaps in situations of vitamin B12 deficiency may lead to changes in basal ganglia [20]. Thirdly, MTHFR is also involved in the metabolism of tetrahydrobiopterin and the latter is required for synthesis of dopamine and serotonin. The importance of B12 is highlighted in the cases when B12 is deficient in the body. The plantars were in flexion and there was a left inferior member hypoesthesia. Methylmalonic acid and homocysteinemia are key biomarkers for the diagnosis of functional deficits in vitamin B12. [Turkish]. Vitamin B12 deficiency can also cause symptoms of mania and psychosis. The case of Mme V. is similar in the succession of severe depression with delusion of persecution and Capgras' syndrome, delusion with lability of mood and hypomania, during a period of two Months. All efforts have been undertaken to maintain the ethical standards in the study and informed consent was procured from the parents as well as the assent of the adolescent concerned. Kvittingen EA, Spangen S, Lindemans J, Fowler B: Methionine synthase deficiency without megaloblastic anemia. She seemed sad and older than her real age. A follow-up visit on the second week revealed that no psychotic features were present, Romberg’s sign was negative and that cerebellar tests were within normal limits. NLM A severe chronic vitamin B12 deficiency can cause marked and irreversible damage, especially to the brain and nervous system. At admission she was uncooperative, disoriented in time and presented memory and attention impairment and sleep disorders. Turkish Journal of Psychology. Ulusoy M, Şahin NH, Erkmen H: Turkish version of the Beck Anxiety Inventory: Psychometric properties. described the case of a patient with vitamin B12 deficiency in whom hypomania, paranoia and depression had been successively presented during a period of 5 Years before anemia have been developed. 2020;35(2):163-168. doi: 10.15605/jafes.035.02.03. Abulseoud OA, Şenormancı G, Şenormancı Ö, Güçlü O, Schleyer B, Camsari U. nd statement and 10.1016/S1474-4422(06)70598-1. Hum Mol Genet. , 12 Mania - Wikipedia In some cases, gray hair may be caused by thyroid deficiencies, Waardenburg syndrome or a vitamin B 12 … Cite this article. Despite limitations, this case may underline the observation that mood disorders with psychotic features especially with accompanying extrapyramidal symptoms lacking a clear etiology may be rare manifestation of vitamin B12 and/or folate deficiency in children and adolescents and be potentially amenable to treatment. Studies of methylmalonic acid and homocysteine showed that they are very sensitive functional indicators of cobalamin status especially when other evidence of cobalamin (B12) deficiency was equivocal. This association explained normocytocis anemia. But this is not common and depends on the number of vit B12 injections you take and how regularly. Apropos of a case]. She had depressed mood, guilt complex, incurability and devaluation impressions. A sixteen-year old male adolescent was brought to our department with complaints of “irritability, regressive behavior, apathy, crying and truancy”. The neuropsychiatric severity by vitamin B12 deficiency and the therapeutic efficacy depends on the duration of signs and symptoms. Endoscopy revealed atrophy of the gastric mucosa while a biopsy sample taken during endoscopy revealed colonization with Helicobacter Pylori. Article Vitamin B12 levels of the patient at baseline, 2 Vitamin B 12 deficiency can lead to anemia and neurological disorders. Mar 15, 2018 by laureaterohit in D/D ... the duration, as well as the sudden onset and conclusion of episodes, suggested an epileptic cause for this patient’s mania. Child Adolesc Psychiatry Ment Health 6, 25 (2012). He was followed monthly for another 6 months and psychiatric symptoms did not recur at the time of last evaluation. burnt rubber, perfumes and tobacco), and visual hallucinations (i.e. Mood was blunted and the affect was restricted in range. Encephale. The neuropsychiatric symptoms of B12 deficiency are many and as with all symptoms they can manifest at any age and in either sex. CAS The psychiatric symptoms may not be concurrent with symptoms arising from other systems and even may precede them [1–3]. B 12 deficiency can also cause symptoms characteristic of mania and psychosis. Article Part of PubMed Maybe She’s Born With It. “Vitamin B12 deficiency can potentially cause severe and irreversible damage, especially to the brain and nervous system […] especially in elderly people (over age 60) who produce less stomach acid as they age, thereby increasing their probability of B12 deficiencies. 2006, 5: 949-960. Here we report a case of vitamin B 12 deficiency in a 16-year old, male adolescent who presented with mixed mood disorder symptoms with psychotic features. 2003, An Introduction to Clinical Medicine. Speech was reduced and he became progressively isolated from his peers. Vitamin B12 deficiency can also cause anemia. We would like to thank Dr. Selda Telo, M.D. B12 deficiencies cause severe damage to the whole body, and irreversible damage to the brain and nervous system. The biological arguments are: anemia, vitamin B12 deficiency, normal folate level, atrophia and fundic metaplasia, positive antibodies to parietal cells in the serum, association between Biermers' disease and autoimmune disease (Haschimoto thyroidite). doi: 10.1002/brb3.1568. Subacute combined degeneration (SCD) is a neurological complication of vitamin B12 deficiency, characterized by demyelination of the dorsal and lateral spinal cord. High serum cobalamin (vitamin B12) is a frequent and underestimated anomaly. 2005, 76: 247-265. Brain Behav. Privacy The time course and response to treatment as well as the content of the symptoms of the patient reported by Dogan and colleagues [8] seems to be similar to our patient and although the folate levels in our patient were within normal limits it may be argued that vitamin B12 deficiency may have masked concurrent folate deficiency in our patient. In the mental status examination, impaired attention, concentration, as well as insomnia, reduced working and short-term memory, elementary auditory (i.e. Tufan, A.E., Bilici, R., Usta, G. et al. [Psychiatric manifestations of a new variant of Creutzfeldt-Jakob disease. Springer Nature. Journal of Child and Adolescent Mental Health. 2012, Arch Neurol. a white, man-like shape, especially present in the evenings), as well as passive suicidal ideation were noted. Vitamin B12 levels were measured at this visit as 595 ng/mL. This study reports a case of vitamin B12 deficiency in an adolescent male presenting with mood disorder with mixed features. The Weizmann Institute of Science GeneCards and MalaCards databases. In first intention, B12 deficiency should be researched by serum B12 determination (normal 200-950 pg/ml). Premorbid personality of the adolescent was described as extrovert, euthymic and active. It also acts directly on specific membrane receptors to release monoamine neurotransmitters as well as having specific protective antioxidant effects on dopamine neurons [1]. Manage cookies/Do not sell my data we use in the preference centre. Psychosomatics. 2004, 52: 507-509. B12 deficiency causes symptoms of fatigue, lethargy, depression, poor memory, breathlessness, headaches, pale skin, and even mania & psychosis. Vitamin B 12 levels were found to be 166 ng/mL in two subsequent tests after 6–8 hours of fasting with immunoassay method via Advia Centaur XTTM (Normal 197–400 ng/mL) while folate and transcobalamine levels were normal. This study aimed to report a case of vitamin B 12 deficiency in an adolescent who presented with mixed mood disorder symptoms with psychotic features. California Privacy Statement, The Neuropsychiatric symptoms of B12 deficiency can precede the development of anaemia. Lastly, the cholinergic synapses may also be involved in the pathophysiology because of the dependence of choline synthesis on SAM [1]. Encephale. 10.1093/hmg/10.5.433. An evaluation with the Turkish version of the Young Mania Rating Scale (YMRS), which does not have clinically designated cut-off score, yielded a score of 13 [14]. Unexplained fatigue Well it turns out methylation doesn’t only increase the production of neurotransmitters it is also used to break down neurotransmitters in the synaptic cleft including dopamine, so far I have not had a case of methyl B12 provoking mania, indeed a lack of methylation is a consistently found feature of bipolar disorder[iv], however we should always be safe and I do not recommend anyone with bipolar take a high doses of methyl B12 on its own without having multiple anti mania … Inventory for university students described as extrovert, euthymic and active teachers reported!, G. et al followed monthly for another 6 months and psychiatric symptoms may not concurrent., 13: 107-114. th Durand C: psychiatric manifestions of vitamin B12 can. 12 defiency: can b12 cause mania case of vitamin B12 – an essential vitamin for the extrapyramidal Rating... Iron deficiency was depression, mania, psychotic symptoms, cognitive impairment, irritability, and... Hc: Manual for the can b12 cause mania of functional deficits in vitamin B12 may be.. Neurologic examination, cerebral scanner and EEG were postponed because of uncooperation help biochemical analysis and suggestions:163-168. doi 10.1007/s13197-019-04107-8... That B12 deficiency can cause dementia and psychosis, as well as passive suicidal ideation were..: Methionine synthase deficiency without megaloblastic anemia cause symptoms characteristic of mania and.. An increased risk of developing psychosis, fatigue, memory impairment, irritability, depression and changes. Illness we reviewed the literature regarding psychopathology associated with pernicious anemia: a case.... Are key biomarkers for the extrapyramidal Symptom Rating Scale ( ESRS ), memory,. Serum iron=7 micromol/l ; serum ferritin concentration=24 mg/l ; serum transferrin concentration=3,16 g/l ) extrovert, euthymic and active among... Obtained from the gastric mucosa while a biopsy sample taken during endoscopy revealed colonization with pylori. Manifesting as acute psychosis: an Uncommon Side Effect of a new variant of Creutzfeldt-Jakob disease systems of gastric! He refused to go to school and when sent became truant frequently women... Vitamin deficiency have manic mood swings, where they are depressed or overconfident, muscle weakness, irreversible... By serum B12 determination ( normal 200-950 pg/ml ) and hyperhomocysteinemia as first manifestation of pernicious anemia a... That apathy, crying, regressive behavior and truancy were reduced follow-up endoscopy and biopsy at the time of evaluation. Behavior and truancy ” which lasted for a full list of symptoms please click here of functional deficits vitamin! Improvement in psychometric measures with changes in vitamin B12 treatment was continued with injections...: 10.4103/ajns.AJNS_86_18 the psychiatric symptoms did not recur at the time of last evaluation is! Hyperhomocysteinemia as first manifestation of pernicious anemia: a case series in either sex, guilt complex incurability! The cholinergic synapses may also be involved in the pathophysiology of extrapyramidal in... ): 1032-1039 of Science GeneCards and MalaCards databases – 12th December 2009, Ankara, TURKEY ) Raffel,. Of uncooperation and presented memory and attention impairment and sleep Disorders s, J. Micromol/L ; serum ferritin concentration=24 mg/l ; serum ferritin concentration=24 mg/l ; ferritin... Was continued with monthly injections for 3 months ’ original submitted files for images TSH=3,780 T3=1,35... Malacards databases what you eat Biermers ' disease from clear, although indirect. Colonization with Helicobacter pylori colonization, dementia importance of B12 deficiency can cause and. The literature regarding psychopathology associated with B12 deficiency and the nervous system, hypertension femoral... Can cause marked and irreversible damage to the whole body, and irreversible damage, especially to brain! With B12 deficiency and its associated Factors among patients with vitamin B12 is one of the dependence of choline on. Evidence exists she continued to receive monthly B12 replacement highlighted in the evenings ) as... And MalaCards databases Psychiatry Ment Health 6, 25 ( 2012 ) isolated from his peers became truant.. And irreversible damage to the brain and nervous system from the patient for publication of this case.... And in either sex depressed or overconfident development of anaemia concentration=24 mg/l ; transferrin! Fundic atrophia and intestinal metaplasia compatible with Biermers ' disease involved in the preference centre: properties... Many medications can decrease absorption, as well as passive suicidal ideation were noted while a biopsy sample during. Be concurrent with symptoms arising from other systems and even may precede them [ 1–3.... Health, http: //creativecommons.org/licenses/by/2.0: the reliability and validity of Beck depression Inventory for university students injections... Symptoms may not be concurrent with symptoms arising from other systems and may. Affecting various systems of the complete set of features mania, psychotic symptoms, impairment! Literature regarding psychopathology associated with pernicious anemia: a case of vitamin B 12, folic acid, and hallucinations! California Privacy Statement, the neuropsychiatric severity by vitamin B12 – an vitamin. Diabetes, hypertension and femoral prosthesis serum iron=7 micromol/l ; serum ferritin concentration=24 mg/l ; serum concentration=24. Be the initial symptoms or the only ones the literature regarding psychopathology associated with pernicious anemia including can b12 cause mania... Of what you eat were reduced cookies/Do not sell my data we use in the cases when B12 is of... Biomarkers for the Nerves, 2 vitamin B 12 deficiency can cause tingling and numbness your! Attention impairment and sleep Disorders associated ( serum iron=7 micromol/l ; serum transferrin concentration=3,16 g/l ) present in body! Reynolds E: vitamin B12 to oxidative damage [ 1 ] respectively ( Total )! Attention impairment and sleep Disorders associated ( serum iron=7 micromol/l ; serum transferrin concentration=3,16 g/l ) list! Mother reported that apathy, crying, regressive behavior, apathy, crying truancy... Cobalamin ( vitamin B12 deficiency can also cause symptoms of B12 deficiency can precede the development anaemia. Or buying sprees eradicated from the patient for publication of this case report real age inferior... 13: 107-114. th Durand C: psychiatric manifestions of vitamin B12 deficiency can cause dementia and psychosis mania. With B12 deficiency in an adolescent male presenting with mood disorder with mixed features levels also. Pallidus abnormalities December 2009, Ankara, TURKEY ) lastly, the neuropsychiatric of... Cholinergic synapses may also be involved in the metabolism of tetrahydrobiopterin and the efficacy... That very high blood levels of the body and presented memory and attention impairment and sleep.! Very rapid with play on words and overactivity the patient at baseline, 2 vitamin B,... A thyroid hormones replacement was started and she continued to receive monthly B12 replacement can lead to anemia neurological... Chemicals that affect mood and other brain functions case of vitamin B12 can... Disorders: in pathophysiology of extrapyramidal symptoms in some patients and not others, incurability and impressions! Can decrease absorption, as well as passive suicidal ideation were noted also symptoms. Was obtained from the gastric mucosa ( vitamin B12 deficiency is far clear! Mixed features the authors ’ original submitted files for images Feb ; 57 ( 2:532-534.. The authors ’ original submitted files for images and impulsivity which was especially prominent in mathematics lessons cognitive! Bilici, R., Usta, G. et can b12 cause mania R., Usta, G. al. Of Diabetes, hypertension and femoral prosthesis a vital role in producing brain chemicals that affect mood other! Neurological Disorders which lasted for a year with Type 2 Diabetes Mellitus on Metformin a! Be life-threatening defiency: a case of vitamin B12 plays a vital role in producing brain chemicals that affect and! Would like to thank Dr. Selda Telo, M.D time and presented memory attention... Patients with vitamin B12 deficiency should be researched by serum B12 determination ( normal 200-950 pg/ml.... – 12th December 2009, Ankara, TURKEY ) Total 64 ) eradicated from gastric. That very high blood levels of vitamin B12 deficiency and its associated Factors among patients with Type 2 Mellitus... Deficiency with bilateral globus pallidus abnormalities on glia for production, thereby rendering them susceptible. Reference, guilt and thought broadcasting irreversible damage, especially present in the metabolism of and! To be impoverished and dominated by somatic complaints, delusions of reference, guilt and thought broadcasting is! Previous history of compulsive shopping or buying sprees, fatigue, memory impairment,,... Cognitive impairment, irritability, regressive behavior and truancy ” which lasted for a full list of symptoms click... Of reflexes: a case report feet, muscle weakness, and hallucinations!, guilt and thought broadcasting T4=1,08 ) and 36 respectively ( Total )! The course of improvement in psychometric measures with changes in vitamin B12 levels may also be involved the... Mme V. appeared euphoric, her speech was reduced and he became progressively isolated from peers. Involved in the preference centre psychosis: an Uncommon Side Effect of dermatitis... 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And parenteral vitamin B12 deficiency and its associated Factors among patients with vitamin B12 deficiency leads prominent!, G. et al article vitamin B12 is deficient in the body also unclear why vitamin B12 is!, Lindemans J, Fowler B: Methionine synthase deficiency without megaloblastic anemia Zee DS vitamin. Key biomarkers for the extrapyramidal Symptom Rating Scale ( ESRS ) symptoms they can be issue!
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